How Does CPP Affect Children?
The good news is that there is treatment for CPP. Below are some reasons why you and your child’s
physician may choose to move forward with treatment.
Puberty is a normal part of growing up. For some children, puberty may start at too early of an age. When this happens, it may be due to a condition called central precocious puberty (CPP). CPP occurs when a child shows signs of puberty sooner than normal—before the age of 8 in girls and before the age of 9 in boys.1,2 CPP is a rare condition that affects 1 in every 5,000 to 10,000 children.3
If you suspect your child has CPP, it’s probably because you’ve noticed changes in your child’s physical development that seem to be happening sooner than they should. This might leave you feeling confused, concerned, or stressed. It’s important to know that there is power in information. Explore this section to better understand the causes of CPP, the potential symptoms and effects, and available treatments.
Although the exact cause is usually unknown, CPP results from the early release of a hormone from the brain called gonadotropin-releasing hormone (GnRH), which causes a child to begin puberty at an age earlier than normal.4,5
A pediatric endocrinologist is a type of physician who specializes in diagnosing, treating, and managing disorders involving hormones, including CPP. If CPP is suspected, your pediatric endocrinologist will evaluate your child, and may order further testing. Some of those tests could include:4
Your child may have experienced a growth spurt related to CPP and may even be tall for his or her age. Treatments for CPP are designed to delay puberty by stopping the signaling of certain hormones that are responsible for jump-starting the puberty process.6
Children with CPP can be taller than their peers; however, children that go untreated may be shorter in height when they become adults.This is because their growth plates (growth plates are areas of cartilage at the ends of long bones) close too early.6 Typically, growth plates close toward the end stages of puberty.
Girls and boys who begin puberty before their peers may be extremely self-conscious about the changes occurring in their bodies. This may affect their self-esteem and may increase their risk of developing depression, eating disorders, or substance abuse, perhaps as a result of standing out before they’re ready for the extra attention.4,7-9
There are no data demonstrating outcomes of Triptodur on stature, social, or emotional health.
Children with CPP may have a hard time understanding the changes taking place in their bodies, such as the growth of pubic or underarm hair, the appearance of acne, or the development of body odor. Girls may be upset to see their breasts growing or to get their first period, while boys may be surprised by facial hair or a deepening voice.
It’s not unusual for children with CPP to feel confused or embarrassed by these changes. Because they tend to look older physically, they are often expected to behave more maturely, which can increase the pressure and expectations placed upon them.9 As a parent, you play a key role in shaping your child’s understanding of CPP and creating a nurturing environment where your child can feel loved and supported.
When you bring your child in for their regular doctor visits during treatment, it is helpful to report to the doctor any changes you see in your child’s body such as height, growth of underarm and pubic hair, breast development, voice change, and oily skin and acne.
Aside from the classic pencil markings on the doorway, there are other fun, interactive ways to track your child’s body changes. Below are some ideas to make tracking your child’s body changes less clinical and more fun!
Create a giant ruler or use blank measuring tape to track body changes with your child. There’s plenty of room to create fun designs and drawings together!
Let your child go to the store and pick out some of their favorite accessories. These accessories can be anything such as tiaras, scarves, a superhero costume, etc. Do regular “photoshoots” with your child using the same accessories and clothing items to track how fast they are outgrowing the items. You’ll be able to track your child’s growth and have some great photos for your memories!
Treatment Options for Central Precocious Puberty1,2 | |||
---|---|---|---|
Injections Per Year | |||
Injection Every Month (4 weeks) |
💉💉💉💉💉💉💉💉💉💉💉💉💉 |
Thirteen Injections Per Year | |
Injection Every 3 Months (12 weeks) |
💉💉💉💉 |
Four Injections Per Year | |
Injection Every 6 Months (24 weeks) |
💉💉 |
Two Injections Per Year | |
Implant | |||
Surgical Subcutaneous Implant* Once Every 12 months |
*Surgical procedure involving the use of anesthesia. The method of anesthesia utilized (ie, local, conscious sedation, general) is at the discretion of the healthcare provider. |
Going through puberty too early can be a confusing and unsettling time for a child and his or her family. There are changes taking place in your child’s body that he or she may not fully understand.1
As a parent, you play a key role in helping your child understand and cope with central precocious puberty (CPP).2 This guide includes some helpful tips to keep in mind as you discuss CPP with your child.
At such a young age, your child might not be fully aware of the changes happening in his or her body, and may even seem unaffected by it. However, children may ask questions about why they are going to the doctor, or why they have to get tests or treatment. If your child is tall or perhaps more developed for their age, he or she may also have other children or adults comment or ask questions.
How you talk about CPP can go a long way toward shaping your child’s understanding of it, so it is a good idea to think about how you will discuss CPP with your child. It may be helpful to start with something like “Everyone’s body goes through these changes. Your body just started a little early.”
It may also be helpful to use objects to open lines of communication between you and your child about the changes in his or her body. Comparing the size of objects such as toys gives children a chance to play with measurement and helps them learn how to compare and use words such as “taller,” “shorter,” etc.3 For example, directly compare the heights of two stuffed toys and describe one toy as taller/shorter. This not only helps children understand measurement, but can help guide the conversation between you and your child about which parts of his or her body are growing or changing.
A CPP diagnosis can raise a lot of questions such as: What’s happening to my child’s body? Who do I talk to if I need help? Do I tell my friends and family?
Children often mimic their parent’s behavior – your child is more likely to be anxious if you exhibit signs of stress.4 Understanding CPP, and how you plan to talk with your child, family members, and even your doctors, can empower you to be a reliable support system for your child
A simple explanation of CPP that can be used with friends and family is “My child has started puberty sooner than normal.”
By talking to your child’s doctor about CPP and what to expect, you can help ease your own uncertainties and anxieties.
Although your child’s body is developing early, he or she is still a young child. Sometimes adults or other children may treat your child as if they are older because of their appearance.1 If you are worried about family members, teachers, or other adults in your child’s life treating him or her as if they are older, it may be helpful to explain the condition to them. Talk to your healthcare provider for suggestions on explaining CPP or share this helpful guide.
Right now, your child might not understand the changes happening in his or her body or they may have negative feelings about developing early. How you talk about CPP can go a long way toward shaping your child’s understanding of it. When discussing CPP, being honest and open about the changes happening to their bodies can be helpful.6 You can start out by saying something like: “Everybody goes through puberty. You just started a little early.”
Being diagnosed with CPP can raise a lot of questions such as: What’s happening to my body? Why am I so moody? Why don’t I look like my friends?1 By talking to your child about what CPP is and what to expect from it, you can help ease his or her fears and anxieties. Enlist the help of your child’s healthcare provider to explain what is happening. Be sure to stay involved.
Although your child’s body is developing early, he or she is still a child and they need your support and guidance. Reassure your child that you’re there when he or she has questions, concerns, or just wants to talk. It may be helpful to tell your child: “I’m here to help you” or “You can ask me anything.”1
Because it’s natural for other people—especially kids—to be curious, it helps to arm your child with some simple responses to questions he or she might get from other kids. A confident, straightforward response to other people’s curiosity can help.6
For example, if one of your daughter’s classmates asks her why she has breasts, you may want to suggest that she smile and say, “Because I’m a girl.” Or your child might choose a more direct approach and simply answer: “I have a medical condition” and leave it at that. The important thing is for your child not to feel ashamed or embarrassed about CPP.1
Children look for guidance on how to think about and respond to CPP. Your love and support means everything and can go a long way to boosting your child’s self-acceptance.1
TRIPTODUR is indicated for the treatment of pediatric patients 2 years of age and older with central precocious puberty (CPP).
Tell your child’s healthcare provider if any of the above conditions apply to your child.
It is important to stick to the dosing schedule (one injection every 24 weeks) in order for the drug to work. Do not miss or delay a scheduled dose.
Some people taking gonadotropin releasing hormone (GnRH) agonists like TRIPTODUR have had new or worsened mental (psychiatric) problems. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, or acting aggressive. Call your child’s doctor right away if your child has any new or worsening emotional symptoms while taking TRIPTODUR.
Some people taking GnRH agonists like TRIPTODUR have had seizures. The risk of seizures may be higher in people who have a history of seizures, have a history of epilepsy, have a history of brain or brain vessel (cerebrovascular) problems or tumors, are taking a medicine that has been connected with seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Call your child’s doctor right away if your child has a seizure while taking TRIPTODUR.
Some people taking triptorelin, the active ingredient in TRIPTODUR, have had serious allergic reactions. Call your child’s doctor or get emergency medical help right away if your child gets any of the following symptoms of a serious allergic reaction: skin rashes, redness, or swelling, severe itching, hives, trouble breathing or swallowing, fast heartbeat, sweating, throat tightness, hoarseness, swelling of face, mouth, and tongue, dizziness or fainting.
The most common side effects of TRIPTODUR include injection site reactions, menstrual (vaginal) bleeding, hot flush, headache, cough, and infections (bronchitis, gastroenteritis, influenza, nasopharyngitis, otitis externa, pharyngitis, sinusitis, and upper respiratory tract infection). These are not all the possible side effects of TRIPTODUR. Tell your child’s healthcare provider if they have any side effect that bothers them or that does not go away.
In the first few weeks after your child receives their first TRIPTODUR injection or after additional injections, TRIPTODUR can cause a brief increase in some hormones. During this time you may notice more signs of puberty in your child, including vaginal bleeding. Call your child’s doctor if signs of puberty continue after 2 months of receiving TRIPTODUR.
Reports of pseudotumor cerebri (idiopathic intracranial hypertension) have been observed in pediatric patients receiving GnRH agonists, including triptorelin. Patients and caregivers should contact their healthcare provider if the patient develops any of following symptoms of pseudotumor cerebri, including headache, and vision issues such as blurred vision, double vision, loss of vision, pain behind the eye or pain with eye movement, ringing in the ears, dizziness, and nausea.
These are not all the possible side effects of TRIPTODUR. Call your doctor for medical advice about side effects.
To report SUSPECTED ADVERSE REACTIONS, contact Azurity Pharmaceuticals, Inc. at 1-800-461-7449, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
The Important Safety Information does not include all the information needed to use TRIPTODUR safely and effectively. For additional safety information, please consult the full Prescribing Information for PDF Document: TRIPTODUR (File Size: 153 KB).